SPIN

Description

The studies take place in two cities on two Indonesian islands (Bandung, Java and Medan, Sumatra) and consist of two sub-projects. The first project focuses on epidemiology and mathematical modeling, addressing the validation and optimization of the use of LQAS-based surveillance, as well as bias introduced by laboratory-based surveillance or negative cultures. The second project focuses on clinical and microbiological aspects, and studies the effect of results of LQAS-based surveillance on antimicrobial stewardship activities and appropriateness of empirical therapy. The SPIN project validates, optimizes, and implements the use of LQAS-based AMR surveillance for urinary tract infections caused by Escherichia coli and Klebsiella pneumoniae. This is paired with extensive capacity building activities in microbiology using state-of-the-art techniques (tele-microbiology approach) to be able to effectively inform local antimicrobial stewardship activities. Other objectives of the study are to assess the appropriateness of empirical therapy for urinary tract infection given the background prevalence of AMR as assessed by LQAS-based surveillance, and to assess clinical and molecular determinant of AMR in urinary tract infections