Expanded use of ART for treatment and prevention in female sex workers in South Africa: a demonstration project.


The overall goal of the TAPS project is to determine whether an integrated intervention of oral HIV pre-exposure prophylaxis (PrEP) and testing followed by treatment irrespective of immune status as measured by CD4 (‘immediate treatment’), can be feasibly implemented and is acceptable within a combination prevention and care approach tailored to the needs of South African female sex workers (FSWs), in the context of limited health system resources.

There are four objectives:

  1. Conduct a demonstration project integrating PrEP and ‘immediate treatment’ into service delivery programs tailored to FSWs.
  2. Conduct a qualitative evaluation of the demonstration project to assess user and provider perceptions, attitudes, preferences, practices and beliefs as well as user adherence as related to the uptake and use of PrEP and ‘immediate treatment’.
  3. Conduct a costing study to assess resource implications of the introduction of PrEP and ‘immediate treatment’ on existing services.
  4. Evaluate the impact of PrEP and ‘immediate treatment’ on the HIV epidemic in FSWs in South Africa using an epidemiological transmission model designed and parametrised specifically for this population.


The WHO ‘End TB strategy 2016-2035’ has a vision of a ‘world free of TB (zero deaths, disease or suffering due to TB)’ and the goal of ‘ending the global TB epidemic’ by 2035, defined as an annual incidence of <10 cases per 100,000 of population. Intermediate targets (TB incidence and mortality reduced by 50% and 75% respectively compared to 2015 levels) were proposed for 2025.


Name: TAPS
Status: Active
Principal Investigators: Helen Rees (Wits Reproductive Health & HIV Institute)
Co-investigators: Gabriela Gomez; Robyn Eakle; Francois Venter
Departments(s): Amsterdam Institute for Global Health and Development,
University of Amsterdam
Partners: Wits Reproductive Health & HIV Institute (Wits RHI)
Contact information: Project Manager: Gabriela Gomez

Email: g.gomez@aighd.org

Duration: Start date: 1 July 2014

Duration: 36 months

End date: 1 July 2017

Funded by: Bill and Melinda Gates Foundation
Countries: South Africa: Johannesburg and Pretoria