Rotabiome

The influence of the intestinal microbiome on infant rotavirus vaccine responses in rural Ghana and urban Pakistan.

Objective

To test the hypothesis that the differential presence of immune-stimulating intestinal microbes influences oral rotavirus vaccine efficacy in infants.

Background

Rotavirus is the leading cause of diarrhea-related death in children worldwide, with 95% of rotavirus deaths occurring in low-income countries in Africa and Asia.  Rotavirus vaccines  have the potential to dramatically reduce the morbidity and mortality caused by rotavirus infection, however rotavirus vaccines demonstrate significantly lower efficacy in low-income countries.

Understanding the pathophysiology behind this diminished efficacy is critical, as even small improvements in efficacy could increase the number of children’s lives saved by the vaccine by hundreds of thousands over the next 15 years.

One of several explanations for these differences in vaccine efficacy is that the infant intestinal microbiota may be modulating an infant’s immune response to the enteric RVV. We hypothesized that the composition of the intestinal microbiota is influencing RVV response, that RV vaccine responders have different intestinal microbes as compared to non-responders and that these dissimilarities contribute to the decreased efficacy of RVV found in Africa and Asia.

Summary

Name: Rotabiome
Status: Initiated
Principal Investigator: Vanessa C. Harris
Departments(s): AIGHD, CEMM
Partners: Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan

Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

Laboratory of Mirobiology, Wageningen University, the Netherlands

Department of Pediatrics, University of Padova, Italy

PATH Vaccine Access and Delivery global program, Seattle, USA

Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, USA

Contact information: Marloes Nijboer, project manager (m.nijboer@aighd.org)
Duration: Initiated
Funded by: This research is funded in part by the Bill & Melinda Gates Foundation; GAVI, the Vaccine Alliance, GlaxoSmithKline Biological SA (GSK) and the Netherlands Organization for Scientific Research [Spinoza Grant 2008 to WMdV].
Countries: Karachi, Pakistan
Navrongo, Ghana
Publications: http://www.scientificamerican.com/article/gut-microbes-may-help-determine-our-immune-response-to-vaccines/