Rotabiome human volunteer

The role of the intestinal microbiome in enteric and systemic vaccine immune responses, tested in adult volunteers.

Objective

Primary Objective: to prospectively investigate the role of the gut microbiota in rotavirus vaccine immune response.

Secondary Objectives:  To prospectively investigate the role of the gut microbiota in tetanus and pneumococcal vaccine immune responses.

Background

Rotavirus (RV) is the leading cause of diarrhea-related death in children under five years of age, particularly in Africa and Asia.  Rotavirus vaccines (RVV) have the potential to dramatically reduce rotavirus morbidity and mortality, however rotavirus vaccine efficacy is lowest in the poorest countries with the highest child mortality rate.

We hypothesize that differences in gut microbiome colonization, composition and diversity might be contributing to the diminished RVV efficacy observed in developing countries.

This study proposes using antibiotics to change the intestinal microbiome in healthy volunteers and evaluating the effect of differing microbiota on RVV immune responses.

To obtain a better mechanistic understanding of the relationship between the intestinal microbiota and vaccine immune responses, this study also proposes evaluating the effect of antibiotic microbiota manipulation on two well-studied and classic systemic vaccines: the tetanus vaccine and the pneumococcal vaccine (Pneumo23).

Summary

Name: Rotabiome human volunteer
Status: Start June, 2015
Currently enrolling patients
Principal Investigator: W.J. Wiersinga, AMC
Vanessa C. Harris, AIGHD
Departments(s): AIGHD
CEMM
Global Child Health Group EKZ-AMC
Partners: Laboratory of Mirobiology, Wageningen University, the Netherlands

Department of Pediatrics, University of Padova, Italy

Division of Viral Diseases, Centers for Disease Control and Prevention (CDC), Atlanta, USA

Contact information: Marloes Nijboer, project manager (m.nijboer@aighd.org)
Duration: Initiated
Funded by: This research is funded by the Stichting Steun Emma Kinderziekenhuis AMC
Countries: Amsterdam, the Netherlands
Publications: