Sabine Hermans

Sabine Hermans MD, MSc, PhD is a post-doctoral fellow at the Amsterdam Institute for Global Health and Development and Department of Global Health, University of Amsterdam. She is currently based at the Desmond Tutu HIV Centre at the University of Cape Town, South Africa.

Sabine trained as an internist and infectious diseases specialist in the Netherlands. From 2008 to 2012 she was based at the Infectious Diseases Institute (IDI), part of Makerere University College of Health Sciences in Kampala, Uganda, seconded by the University of Utrecht and later the Amsterdam Institute for Global Health and Development. She set up and headed the integrated TB/HIV clinic at the IDI, which she combined with research leading toward the completion of her PhD at the University of Utrecht in June 2012. She subsequently moved to the London School of Hygiene and Tropical Medicine, where she obtained her MSc in Epidemiology in 2013.

A 3 year post-doctoral fellowship granted by the European Commission allowed Sabine to join the Desmond Tutu HIV Centre at the University of Cape Town, seconded by AIGHD, in October 2013. She is currently working on epidemiological analyses of a decade of data on tuberculosis in the City of Cape Town, with the aim of developing a mathematical model of TB in the city. She also works as a clinician at the Hannan Crusaid Antiretroviral Treatment Centre in Gugulethu, Cape Town.

Her research interests include epidemiology of HIV and TB co-infection and operational research into the implementation of optimal strategies of health care delivery. She has also undertaken historical and cost-effectiveness research in this field. She was the principal investigator of a prospective non-randomised interventional study of the effect of a Short Message Service (SMS) reminder service on improving TB treatment completion in Uganda. In 2011 she was awarded the annual International AIDS Society TB-HIV research prize for her operational research on antiretroviral treatment initiation at the IDI integrated TB-HIV clinic.

Publications

  • Treatment decisions and mortality in HIV-positive presumptive smear-negative TB in the Xpert™ MTB/RIF era: a cohort study

    The Xpert™ MTB/RIF (XP) has a higher sensitivity than sputum smear microscopy (70% versus 35%) for TB diagnosis and has been endorsed by the WHO for TB high burden countries to increase case finding among HIV co-infected presumptive TB patients. Its impact on the diagnosis of smear-negative TB in a routine care setting is unclear. We determined the change in diagnosis, treatment and mortality of smear-negative presumptive TB with routine use of Xpert MTB/RIF (XP).

    Sabine M. Hermans, Juliet A. Babirye, Olive Mbabazi, Francis Kakooza, Robert Colebunders, Barbara Castelnuovo, Christine Sekaggya-Wiltshire, Rosalind Parkes-Ratanshi and Yukari C. Manabe

    BMC Infectious Diseases DOI: 10.1186/s12879-017-2534-2

    https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-017-2534-2

  • The timing of tuberculosis after isoniazid preventive therapy among gold miners in South Africa: a prospective cohort study

    Authored by: Hermans Sabine M., Grant Alison D., Chihota Violet, Lewis James J., Vynnycky Emilia, Churchyard Gavin J., Fielding Katherine L.
    In: BMC MEDICINE 14(1), 2016, p.45 .
    http://www.ncbi.nlm.nih.gov/pubmed/27004413

  • Tuberculosis in Cape Town: An age structured transmission model

    Authored by: Blaser Nello, Zahnd Cindy, Hermans Sabine, Salazar‑Vizcaya Luisa, Estill Janne, Morrow Carl, Egger Matthias, Keiser Olivia, Wood Robin.
    In: EPIDEMICS 14, 2016, p.54‑61.
    http://www.ncbi.nlm.nih.gov/pubmed/26972514

  • Tuberculosis in Cape Town: An age‑structured transmission model

    Authored by: Blaser Nello, Zahnd Cindy, Hermans Sabine, Salazar‑Vizcaya Luisa, Estill Janne, Morrow Carl, Egger Matthias, Keiser Olivia, Wood Robin
    In: EPIDEMICS 14, 2016, p.54‑61.
    http://linkinghub.elsevier.com/retrieve/pii/S1755436515000869?via=sd

  • A Century of Tuberculosis Epidemiology in the Northern and Southern Hemisphere: The Differential Impact of Control Interventions

  • Impact of Anti-Retroviral Treatment and Cotrimoxazole Prophylaxis on Helminth Infections in HIV-Infected Patients in Lambaréné, Gabon.

    Authored by: Janssen Saskia, Hermans S. M., Knap M. et al.
    In: PloS Neglected Tropical Diseases, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25993501

  • Antiretroviral therapy and tuberculosis: does the regimen matter?

  • Risk of tuberculosis after antiretroviral treatment initiation: a comparison between efavirenz and nevirapine using inverse probability weighting

    Authored by: Hermans Sabine M., Manabe Yukari C., Kiragga Agnes N., Hoepelman Andy I. M., Lange Joep M. A., van Leth Frank
    In: ANTIVIRAL THERAPY -, 2013, p.–
    http://www.ncbi.nlm.nih.gov/pubmed/23423604

  • Integration of HIV and TB services results in improved TB treatment outcomes and earlier prioritized ART initiation in a large urban HIV clinic in Uganda

    Authored by: Hermans Sabine M., Castelnuovo Barbara, Katabira Catherine, Mbidde Peter, Lange Joep M. A., Hoepelman Andy I. M., Coutinho Alex, Manabe Yukari C.
    In: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 60(2), 2012, p.e29-e35
    http://www.ncbi.nlm.nih.gov/pubmed/22395671

  • Unrecognised tuberculosis at antiretroviral therapy initiation is associated with lower CD4+ T cell recovery

    Authored by: Hermans Sabine M., van Leth Frank, Kiragga Agnes N., Hoepelman Andy I. M., Lange Joep M. A., Manabe Yukari C.
    In: TROPICAL MEDICINE & INTERNATIONAL HEALTH 17(12), 2012, p.1527-1533
    http://www.ncbi.nlm.nih.gov/pubmed/23130871

  • Implementation and effect of intensified case finding on diagnosis of tuberculosis in a large urban HIV clinic in Uganda: a retrospective cohort study

    Authored by: Hermans Sabine, Nasuuna Esther, van Leth Frank, Byhoff Elena, Schwarz Miriam, Hoepelman Andy, Lange Joep, Manabe Yukari C.
    In: BMC PUBLIC HEALTH 12, 2012, p.674-
    http://www.ncbi.nlm.nih.gov/pubmed/22905704

  • Comment on: Predictors of immune recovery and the association with late mortality while on antiretroviral treatment in Cambodia

    Authored by: Hermans S. M., Sempa J., Castelnuovo B., Manabe Y. C., van Leth F.
    In: TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 106(5), 2012, p.328-329
    http://www.ncbi.nlm.nih.gov/pubmed/22445080

  • Earlier initiation of antiretroviral therapy, increased tuberculosis case finding and reduced mortality in a setting of improved HIV care: a retrospective cohort study

    Authored by: Hermans S. M., van Leth F., Manabe Y. C., Hoepelman A. I. M., Lange J. M. A., Kambugu A.
    In: HIV MEDICINE 13(6), 2012, p.337-344
    http://www.ncbi.nlm.nih.gov/pubmed/22296211

  • Evaluating the cost-effectiveness of combination antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Uganda

    Authored by: Kuznik Andreas, Lamorde Mohammed, Hermans Sabine, Castelnuovo Barbara, Auerbach Brandon, Semeere Aggrey, Sempa Joseph, Ssennono Mark, Ssewankambo Fred, Manabe Yukari C.
    In: BULLETIN OF THE WORLD HEALTH ORGANIZATION 90(8), 2012, p.595-603
    http://www.ncbi.nlm.nih.gov/pubmed/22893743

  • Rifampicin for continuation phase tuberculosis treatment in Uganda: a cost-effectiveness analysis

    Authored by: Manabe Yukari C., Hermans Sabine M., Lamorde Mohammed, Castelnuovo Barbara, Mullins C. Daniel, Kuznik Andreas
    In: PLOS ONE 7(6), 2012, p.e39187-
    http://www.ncbi.nlm.nih.gov/pubmed/22723960

  • Cost-effectiveness of early initiation of first-line combination antiretroviral therapy in Uganda

    Authored by: Sempa Joseph, Ssennono Mark, Kuznik Andreas, Lamorde Mohammed, Sowinski Stefanie, Semeere Aggrey, Hermans Sabine, Castelnuovo Barbara, Manabe Yukari C.
    In: BMC PUBLIC HEALTH 12, 2012, p.736-
    http://www.ncbi.nlm.nih.gov/pubmed/22943068