Pascale Ondoa

Dr Pascale Ondoa is a viro-immunologist with a long experience in the field of HIV. She is currently serving as a senior laboratory scientist at the Amsterdam Institute for Global Health and development (AIGHD).  Dr Ondoa obtained her medical degree in 1992 from the ‘Centre Universitaire des Sciences de la Santé’ (CUSS)’ in Cameroon and worked a few years as a medical officer in a tuberculosis hospital in Yaoundé. She obtained her PhD in Biomedical Sciences (Virology) from the University of Antwerp, Belgium in 2001. She completed her post-doc training in the unit of Immunology at the Institute of Tropical Medicine in Antwerp between 2002 and 2009. During this period, Dr Ondoa was mainly involved in the development and evaluation of alternative and affordable methods to monitor HIV disease progression and antiretroviral therapy in resource-poor settings. She was also interested in studying (incomplete or inappropriate) immune restoration upon suppressive anti-HIV treatment.

Presently, Dr Ondoa works on several projects evaluating HIV drug resistance in Africa. She also conducts research on laboratory systems, with a specific focus on alleviating barriers to the laboratory workforce in sub-Saharan Africa. Since 2012, she is the PI of a WOTRO project addressing historical, social and cultural limiting the contribution of medical laboratory to antenatal care in three countries of West Africa (Senegal, Mali and Burkina Faso).

Publications

  • Molecular Epidemiology and Transmission Dynamics of Recent and Long‑Term HIV‑1 Infections in Rural Western Kenya

    Authored by: Zeh Clement, Inzaule Seth C., Ondoa Pascale, Nafisa Lillian G., Kasembeli Alex, Otieno Fredrick, Vandenhoudt Hilde, Amornkul Pauli N., Mills Lisa A., Nkengasong John N.
    In: PLOS ONE 11(2), 2016, p.e0147436‑.
    http://www.ncbi.nlm.nih.gov/pubmed/26871567

  • Clinical Evaluation of an Affordable Qualitative Viral Failure Assay for HIV Using Dried Blood Spots in Uganda

    Authored by: Balinda Sheila N., Ondoa Pascale, Obuku Ekwaro A., Kliphuis Aletta, Egau Isaac, Bronze Michelle , Kasambula Lordwin, Schuurman Rob, Spieker Nicole, Rinke de Wit Tobias F., Kityo Cissy
    In: PLOS ONE 11(1), 2016, p.e0145110‑.
    http://www.ncbi.nlm.nih.gov/pubmed/26824465

  • HIV drug resistance and hepatitis co-infections in HIV-infected adults and children initiating antiretroviral therapy in Rwanda

    Authored by: Rusine John B.
    Thesis Universiteit van Amsterdam
    Promotor(s): M.D. de Jong
    Copromotor(s): P.L.A. Ondoa, J.H.H.M. van de Wijgert
    Date of thesis defense: 29/10/2015

    Since the roll-out of antiretroviral therapy (ART), few data have been generated on outcomes and outcome predictors of ART in adults and children in Rwanda. Equally, the extent of chronic hepatitis virus infections and their impact on the ART outcomes in the country are not known. This information is crucial to inform the choice of empiric first- and second-line ART regimen, ensure adequate clinical management of opportunistic infections and improve the overall performance of the ART programme. Read more

     

  • Lower Pre-Treatment T Cell Activation in Early- and Late-Onset Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

  • Pretreatment HIV Drug Resistance Increases Regimen Switches in Sub-Saharan Africa

    Authored by: Boender T. Sonia, Hoenderboom, B.M., Sigaloff Kim C., Hamers Raph L., Wellington Maureen, Shamu Tinei, Siwale Margaret, Eman E.F. Labib Maksimos, Nankya Immaculate, Kityo Cissy, Adeyemo, Titilope A., Akanmu A.S., Mandaliya Kishor, Botes Mariette E., Ondoa Pascale, Rinke de Wit Tobias F.
    In: Clinical Infectious Diseases, 2015
    http://cid.oxfordjournals.org/content/early/2015/08/02/cid.civ656.abstract
    http://www.ncbi.nlm.nih.gov/pubmed/26240203

  • Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months

    Authored by: Asiimwe-Kateera B, Veldhuijzen N. J., Balinda Jean-Paul, Rusine John, Eagle, Sally, Vyankandondera Joseph, Mugabekazi Julie, Ondoa Pascale, Boer Kimberly, Asiimwe, Anita, Lange Joep, Reiss Peter, van de Wijgert J.
    In: AIDS Research and Therapy, 2015
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519532/
    http://www.ncbi.nlm.nih.gov/pubmed/26257954

  • Twelve-Month Antiretroviral Therapy Suppresses Plasma and Genital Viral Loads but Fails to Alter Genital Levels of Cytokines, in a Cohort of HIV-Infected Rwandan Women.

    Authored by: Ondoa P., Raju Gautam, Rusine John, Lutter R et al.
    In: PloS One, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26010956

  • Performance and Logistical Challenges of Alternative HIV-1 Virological Monitoring Options in a Clinical Setting of Harare, Zimbabwe

    Authored by: Ondoa Pascale, Shamu Tinei, Bronze Michelle, Wellington Maureen, Boender T. Sonia, Manting Corry, Steegen Kim, Luethy Rudi, Rinke de Wit Tobias
    In: Hindawi, 2014
    http://www.hindawi.com/journals/bmri/2014/102598/abs/

  • High Seroprevalence of HBV and HCV Infection in HIV-Infected Adults in Kigali, Rwanda

    Authored by: Rusine John, Ondoa Pascale, Asiimwe-Kateera Brenda, Boer Kimberly R., Uwimana Jean Marie, Mukabayire Odette, Zaaijer Hans, Mugabekazi Julie, Reiss Peter, van de Wijgert Janneke H.
    In: PLOS ONE 8(5), 2013, p.e63303-
    http://www.ncbi.nlm.nih.gov/pubmed/23717409

  • Low Primary and Secondary HIV Drug-Resistance after 12 Months of Antiretroviral Therapy in Human Immune-Deficiency Virus Type 1 (HIV-1)-Infected Individuals from Kigali, Rwanda

    Authored by: Rusine John, Asiimwe-Kateera Brenda, van de Wijgert Janneke, Boer Kimberly Rachel, Mukantwali Enatha, Karita Etienne, Gasengayire Agnes, Jurriaans Suzanne, de Jong Menno, Ondoa Pascale
    In: PLOS ONE 8(8), 2013, p.e64345-
    http://www.ncbi.nlm.nih.gov/pubmed/23950859

  • Molecular and phylogeographic analysis of human immuno-deficiency virus type 1 strains infecting treatment-naive patients from Kigali, Rwanda

    Authored by: Rusine John, Jurriaans Suzanne, van de Wijgert Janneke, Cornelissen Marion, Kateera Brenda, Boer Kimberly, Karita Etienne, Mukabayire Odette, de Jong Menno, Ondoa Pascale
    In: PLOS ONE 7(8), 2012, p.e42557-
    http://www.ncbi.nlm.nih.gov/pubmed/22905148

  • Population-Based Biochemistry, Immunologic and Hematological Reference Values for Adolescents and Young Adults in a Rural Population in Western Kenya

    Authored by: Zeh Clement, Amornkul Pauli N., Inzaule Seth, Ondoa Pascale, Oyaro Boaz, Mwaengo Dufton M., Vandenhoudt Hilde, Gichangi Anthony, Williamson John, Thomas Timothy, DeCock Kevin M., Hart Clyde, Nkengasong John, Laserson Kayla
    In: PLOS ONE 6(6), 2011, p.e21040-
    http://www.ncbi.nlm.nih.gov/pubmed/21713038

  • Performance of six commercial enzyme immunoassays and two alternative HIV-testing algorithms for the diagnosis of HIV-1 infection in Kisumu, Western Kenya

    Authored by: Zeh C., Oyaro B., Vandenhoudt H., Amornkul P., Kasembeli A., Bondo P., Mwaengo D., Thomas T. K., Hart C., Laserson K. F., Ondoa P., Nkengasong J. N.
    In: JOURNAL OF VIROLOGICAL METHODS 176(1-2), 2011, p.24-31
    http://www.ncbi.nlm.nih.gov/pubmed/21635920