Frank Cobelens

Frank Cobelens MD MSc PhD (1959), Professor of Global Health, studied medicine in Amsterdam and communicable disease epidemiology in London, and earned his PhD at the University of Amsterdam. He worked for several years in HIV/AIDS control and tropical and travel medicine. He became involved in epidemiological research on tuberculosis in Asia, Africa and Latin America as senior epidemiologist with the Dutch NGO KNCV Tuberculosis Foundation, one of the world’s leading technical agencies for tuberculosis control. Since 2008 he has led the tuberculosis research group which later became AIGHD and the Department of Global Health of the Academic Medical Center, Amsterdam, where he was appointed full professor of epidemiology and control of poverty-related infectious diseases in 2011. Since 2016 he has chaired AIGHD’s Executive Board as well as the Department of Global Health at the Academic Medical Center, University of Amsterdam.

Cobelens works closely with research groups around the world, and has supervised numerous junior researchers and doctoral students at home and abroad. His scientific interest is in multidisciplinary approaches to problems at the interface of biomedical aspects of infectious diseases, socioeconomic context and control policy. Recent work includes causes and spread of anti-tuberculosis drug resistance, development and evaluation of novel interventions for tuberculosis control, and biomedical mechanisms that define the relation between poverty and infectious diseases.

Cobelens has served on several expert panels and advisory bodies for global infectious disease control, in particular tuberculosis, including the World Health Organization’s Strategic and Technical Advisory Group for Tuberculosis. He is also Scientific Advisor of KNCV Tuberculosis Foundation.

Publications

  • Tuberculosis resistance-conferring mutations with fitness cost among HIV-positive individuals in Uganda

    Ssengooba W, Lukoye D, Meehan CJ, Kateete DP, Joloba ML, de Jong BC, Cobelens FG, van Leth F
    Int J Tuberc Lung Dis. 2017 May 1;21(5):531-536. doi: 10.5588/ijtld.16.0544.

    https://www.ncbi.nlm.nih.gov/pubmed/28399968

  • Prevention of Early Mortality by Presumptive Tuberculosis Therapy Study: An Open Label, Randomized Controlled Trial

    Authored by: Manabe YC, Worodria W, van Leth F, Mayanja-Kizza H, Traore AN, Ferro J, Pakker N, Frank M, Grobusch MP, Colebunders R, Cobelens F.
    Am J Trop Med Hyg. 2016 Dec 7;95(6):1265-1271.

    http://www.ajtmh.org/content/journals/10.4269/ajtmh.16-0239
    https://www.ncbi.nlm.nih.gov/pubmed/27928077

  • Anaemia in Patients with HIV-associated tuberculosis in South Africa: Predictive/prognostic value, aetiologies and treatment

    Authored by: Andrew D. Kerkhoff
    Thesis Universiteit van Amsterdam
    Promotores: F.G.J. Cobelens, S.D. Lawn
    Date of thesis defense: 21/06/2016

    Tuberculosis remains the leading cause of death among people living with HIV in sub-Saharan Africa and worldwide. This thesis found that moderate or severe anaemia was highly predictive of both prevalent and incident tuberculosis among ambulatory outpatients as well as hospitalised in-patients in South Africa and was also a very strong independent predictor of mortality. Read more

  • Cost effectiveness of the Xpert(®) MTB/RIF assay for tuberculosis diagnosis in Brazil

    Authored by: Pinto M., Steffen R. E., Cobelens F., van den Hof S., Entringer A., Trajman A.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 20(5), 2016, p.611 618.
    http://www.ncbi.nlm.nih.gov/pubmed/27084814

  • Feasibility and operational performance of TB LAMP in decentralized settings results from a multi center study

    Authored by: Gray Christen M., Katamba Achilles, Narang Pratibha, Giraldo Jorge, Zamudio Carlos, Joloba Moses, Narang Rahul, Paramasivan C. N., Hillemann Doris, Nabeta Pamela, Amisano Danielle, Alland David, Cobelens Frank, Boehme Catharina C.
    In: JOURNAL OF CLINICAL MICROBIOLOGY [aheadofprint], 2016, p.
    http://www.ncbi.nlm.nih.gov/pubmed/27194691

  • Poor tuberculosis treatment outcomes in Southern Mozambique (2011 2012

    Authored by: García Basteiro Alberto L., Respeito Durval, Augusto Orvalho J., López Varela Elisa, Sacoor Charfudin, Sequera Victor G., Casellas Aina, Bassat Quique, Manhiça Ivan, Macete Eusebio, Cobelens Frank, Alonso Pedro L.
    In: BMC INFECTIOUS DISEASES 16(1), 2016, p.214 .
    http://www.ncbi.nlm.nih.gov/pubmed/27198545

  • Research investments in global infectious diseases – a systematic analysis of the UK research portfolio

    Authored by: Michael G. Head
    Thesis Universiteit van Amsterdam
    Promotor: Prof. dr. F.G.J. Cobelens
    Copromotor(s): Prof. R. Atun, Dr. G.B. Gomez Guillen
    Date of thesis defense: 17/05/2016

    This thesis addresses a topic that continues to be of great importance, that of the distribution of research investments for infectious diseases. There are limited resources for financing research and it is imperative that funding is directed as intelligently as possible, in order to provide the greatest possible impact on disease burden and patient health.

  • Clinical implications of molecular drug resistance testing for M. tuberculosis: a TBNET/RESIST-TB consensus statement

    Authored by: Domínguez J, Boettger, Cirillo D, Cobelens F; Eisenach K, Gagneux S, Hillemann D, Horsburgh R, Molina-Moya B, Niemann S, Tortoli E, Whitelaw A, Lange C.
    In: Int J Tuberc Lung Dis 2016;20:24-42.
    http://www.ncbi.nlm.nih.gov/pubmed/26688526

  • A simplified cost‑effectiveness model to guide decision‑making for shortened anti‑tuberculosis treatment regimens

    Authored by: Zwerling A., Gomez G. B., Pennington J., Cobelens F., Vassall A., Dowdy D. W.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 20(2), 2016, p.257‑260.
    http://www.ncbi.nlm.nih.gov/pubmed/26792481

  • The transmission of Mycobacterium tuberculosis in high burden settings

    Authored by: Yates Tom A., Khan Palwasha Y., Knight Gwenan M., Taylor Jonathon G., McHugh Timothy D., Lipman Marc, White Richard G., Cohen Ted, Cobelens Frank G., Wood Robin, Moore David A. J., Abubakar Ibrahim
    In: LANCET INFECTIOUS DISEASES 16(2), 2016, p.227‑238.
    http://www.ncbi.nlm.nih.gov/pubmed/26867464

  • End TB with precision treatment!

    Authored by: van der Burgt Evelien P. M., Sturkenboom Marieke G. G., Bolhuis Mathieu S., Akkerman Onno W., Kosterink Jos G. W., de Lange Wiel C. M., Cobelens Frank G. J., van der Werf Tjip S., Alffenaar Jan‑Willem C.
    In: EUROPEAN RESPIRATORY JOURNAL 47(2), 2016, p.680‑682.
    http://www.ncbi.nlm.nih.gov/pubmed/26828056

  • Shortened first‑line TB treatment in Brazil: potential cost savings for patients and health services

    Authored by: Trajman Anete, Bastos Mayara Lisboa, Belo Marcia, Calaça Janaína, Gaspar Júlia, Dos Santos Alexandre Martins, Dos Santos Camila Martins, Brito Raquel Trindade, Wells William A., Cobelens Frank G., Vassall Anna, Gomez Gabriela B.
    In: BMC HEALTH SERVICES RESEARCH 16(1), 2016, p.27‑.
    http://www.ncbi.nlm.nih.gov/pubmed/26800677

  • Whole genome sequencing to complement tuberculosis drug resistance surveys in Uganda

    Authored by: Ssengooba Willy, Meehan Conor J., Lukoye Deus, Kasule George William, Musisi Kenneth, Joloba Moses L., Cobelens Frank G., de Jong Bouke C.
    In: INFECTION GENETICS AND EVOLUTION, 2016, Feb 23;40:8-16
    http://www.ncbi.nlm.nih.gov/pubmed/26917365

  • Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

    Authored by: Lienhardt Christian, Lönnroth Knut, Menzies Dick, Balasegaram Manica, Chakaya Jeremiah, Cobelens Frank, Cohn Jennifer, Denkinger Claudia M., Evans Thomas G., Källenius Gunilla, Kaplan Gilla, Kumar Ajay M. V., Matthiessen Line, Mgone Charles S., Mizrahi Valerie, Mukadi Ya‑Diul, Nguyen Viet Nhung, Nordström Anders, Sizemore Christine F., Spigelman Melvin, Squire S. Bertel, Swaminathan Soumya, van Helden Paul D., Zumla Alimuddin, Weyer Karin, Weil Diana, Raviglione Mario
    In: PLOS MEDICINE 13(3), 2016, p.e1001965‑.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775029/

  • Monitoring latent tuberculosis infection diagnosis and management in the Netherlands

    Authored by: Erkens Connie G. M., Slump Erika, Verhagen Maurits, Schimmel Henrieke, de Vries Gerard, Cobelens Frank, van den Hof Susan
    In: EUROPEAN RESPIRATORY JOURNAL, 2016, p.‑.
    http://www.ncbi.nlm.nih.gov/pubmed/26917614

  • No evidence that pyrazinamide resistance is acquired after fluoroquinolone resistance

    Authored by: Cobelens Frank, Gebhard Agnes, van den Hof Susan
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 20(2), 2016, p.282‑.
    http://www.ncbi.nlm.nih.gov/pubmed/26792486

  • High tuberculosis burden among people living with HIV in southern Mozambique

    Authored by: García‑Basteiro Alberto L., López‑Varela Elisa, Respeito Durval, González Raquel, Naniche Denise, Manhiça Ivan, Macete Eusebio, Cobelens Frank, Alonso Pedro L.
    In: EUROPEAN RESPIRATORY JOURNAL 45(2), 2015, p.547‑549.
    http://www.ncbi.nlm.nih.gov/pubmed/25395030

  • The Impact and Cost-Effectiveness of a Four-Month Regimen for First-Line Treatment of Active Tuberculosis in South Africa

    Authored by: Knight GM, Gomez G. B., Dodd PJ, Dowdy David, Zwerling Alice, Wells William A., Cobelens F. et al.
    In: PloS One, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26717007
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145796

  • Anemia, Blood Transfusion Requirements and Mortality Risk in Human Immunodeficiency Virus-Infected Adults Requiring Acute Medical Admission to Hospital in South Africa

    Authored by: Kerkhoff A.D., Lawn Stephen D., Schutz C, Burton R, Boulle A., Cobelens F., Meintjes Graeme
    In: Open Forum Infect Dis., 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26730391
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693115/

  • Patient-centred tuberculosis treatment in Tanzania

    Authored by: Mkopi Abdallah
    Thesis Universiteit van Amsterdam
    Promotor(s): F.G.J. Cobelens
    Copromotor(s): F.C.M. van Leth, E. Geubbels
    Date of thesis defense: 05/11/2015

    The main aim of this thesis was to describe and assess the efficacy of the Patient-Centred Treatment (PCT) strategy for the delivery and supervision of tuberculosis (TB) treatment as implemented by the National Tuberculosis and Leprosy programme of Tanzania. The studies presented in this thesis show that the PCT strategy is acceptable and effective in TB control in Tanzania. Read more

     

  • The potential of a multiplex high-throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study

    Authored by: van’t Hoog A. H., Bergval I, Tukvadze N, Sengstake S, Aspindzelashvili R, Anthony R. M., Cobelens F.
    In: BMC Infectious Diseases, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26503434
    http://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-015-1205-4

  • Data for action: collection and use of local data to end tuberculosis

    Authored by: Theron G, Jenkins HE, Cobelens F., Abubakar I, Khan AJ, Cohen T, Dowdy David
    In: Lancet, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26515676
    http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)00321-9/abstract

  • The Distribution of Fitness Costs of Resistance-Conferring Mutations Is a Key Determinant for the Future Burden of Drug-Resistant Tuberculosis: A Model-Based Analysis

    Authored by: Knight GM, Colijn C, Shrestha S, Fofana MO, Cobelens F. et al.
    In: Clinical Infectious Diseases, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26409276
    http://cid.oxfordjournals.org/content/61/suppl_3/S147.long

  • Challenges in detection and treatment of multidrug resistant tuberculosis patients in Vietnam

    Authored by: Hoang TT, Nguyen NV, Dinh SN, Nguyen HB, Cobelens F. et al.
    In: BMC Public Health, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26415893
    http://www.biomedcentral.com/1471-2458/15/980

  • Operational research on implementation of tuberculosis guidelines in Mozambique

    Authored by: Maria Antonia Brouwer
    Thesis Universiteit van Amsterdam
    Promotor(s): F.G.J. Cobelens
    Copromotor(s): F.C.M. van Leth
    Date of thesis defense: 16/09/2015

    The overall objective of this thesis is to assess how guideline implementation and evaluation contribute to health care decision-making and to assess what critical factors contribute to successful or unsuccessful implementation of TB controlguidelines through case studies mainly conducted in Mozambique. We specifically evaluate two components of the guideline development process: implementationand evaluation of guidelines. Read more

  • Implementation of new diagnostics for tuberculosis: Bridging the gap betweeen global policy and local practice

    Authored by: Sanne Christine van Kampen
    Thesis Universiteit van Amsterdam
    Promotor(s): F.G.J. Cobelens, P.R. Klatser
    Date of thesis defense: 10/09/2015

    Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide with an estimated 9.0 million people who developed TB in 2013, of whom around one-third remained undiagnosed. The release of global guidance on new TB diagnostics has accelerated since 2007, but there remains a gap in local implementation. This thesis investigated the extent of this gap and generated evidence to support implementation of the most recently recommended test for TB and drug-resistant TB, the Xpert MTB/RIF assay. Read more

     

  • How Do the New Definitions for Multidrug-Resistant Tuberculosis Treatment Outcomes Really Perform?

  • The Second Zambian National Tuberculosis Drug Resistance survey – a comparison of conventional and molecular methods

  • High Genotypic Discordance of Concurrent Mycobacterium tuberculosis Isolates from Sputum and Blood of HIV-Infected Individuals

    Authored by: Ssengooba W., Cobelens F. G., Nakiyingi L., Mboowa G, Armstrong D.T., Manabe Y. C., Joloba Moses L., de Jong BC
    In: PloS One, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/26176604
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132581

  • Target product profile of a molecular drug-susceptibility test for use in microscopy centers.

    Authored by: Denkinger CM, Dolinger D, Schito Marco, Wells William A., Cobelens F. et al.
    In: Journal Infectious Diseases, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25765105

  • Triage tests: a new priority for tuberculosis diagnostics.

    Authored by: Garcia-Basteiro AL, Cobelens F.
    In: The Lancet Respiratory Medicine, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25773207

  • The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during long-term antiretroviral therapy in South Africa: a cohort study

    Authored by: Kerkhoff A.D., Wood R., Cobelens F. G. et al.
    In: BMC Medicine, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25889688

  • Variation and risk factors of drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis

    Authored by: Lukoye Deus, Ssengooba W., Musisi K, Kasule GW, Cobelens F. G., Joloba Moses L., Gomez G. B.
    In: BMC Public Health, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25880829

  • Impact on Patients’ Treatment Outcomes of XpertMTB/RIF Implementation for the Diagnosis of Tuberculosis: Follow-Up of a Stepped-Wedge Randomized Clinical Trial.

    Authored by: Trajman A, Durovni B, Saraceni V, Alexandre Menezes , Cordeiro-Santos M, Cobelens F., van den Hof S.
    In: PloS One, 2015
    http://www.ncbi.nlm.nih.gov/pubmed/25915745

  • Anti-tuberculosis drug resistance in Sub-Saharan Africa: The case of Uganda

    Authored by: Deus Lukoye
    Thesis Universiteit van Amsterdam
    Promotor(s): F.G.J. Cobelens
    Copromotor(s): L. Joloba Moses
    Date of thesis defense: 12/02/2015

    This thesis reports findings of six studies including two tuberculosis (TB) drugresistance surveys, a comparative study of HIV infection rates among patients enrolled in the survey and those under routine TB/HIV surveillance, two TB molecular epidemiological analyses and a systematic review and meta-analysis ofdrug-resistant TB in subSaharan Africa. Read more

  • Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa.

    Authored by: Kerkhoff A.D., Wood R., Cobelens F. G., Gupta-Wright A, Bekker Linda-Gail, Lawn Stephen D.
    In: BMC Infectious Diseases, 2014
    http://www.ncbi.nlm.nih.gov/pubmed/25528467
    http://www.biomedcentral.com/1471-2334/14/3860

  • Impact of replacing smear microscopy with Xpert MTB/RIF for diagnosing tuberculosis in Brazil: a stepped-wedge cluster-randomized trial.

    Authored by: Durovni B, Saraceni V, van den Hof S., Trajman A, Cordeiro-Santos M, Solange Cavalcante, Alexandre Menezes , Cobelens F.
    In: PLoS Med, 2014
    http://www.ncbi.nlm.nih.gov/pubmed/25490549

  • Clinical utility of a novel molecular assay in various combination strategies with existing methods for diagnosis of HIV-related tuberculosis in Uganda.

  • High positive predictive value of Xpert in a low rifampicin resistance prevalence setting.

  • Response from Authors to letter from Eduardo Hernández-Garduño (TUBE 2013_75) Tuberculosis monoresistance and culture conversion in smokers Nijenbandring de Boer R, et al., “Delayed culture conversion due to cigarette smoking in active pulmonary tube

  • Tuberculosis Infection Control: Potential Benefit of a New Rapid Tuberculosis Test in a Human Immunodeficiency Virus/AIDS Reference Hospital

    Authored by: Cordeiro-Santos M, Trajman A, Cobelens F., Durovni B, Gonçalves M, Bührer-Sékula S, Saraceni V
    In: Infect Control Hosp Epidemiol, 2014, 35:1206-7
    http://www.ncbi.nlm.nih.gov/pubmed/25111939

  • A household survey on screening practices of household contacts of smear positive tuberculosis patients in Vietnam

    Authored by: Thanh TH, Ngoc SD, Viet NN, Van HN, Horby P, Cobelens F. G., Wertheim HF
    In: BMC Public Health, 2014, 14:713 doi:10.1186/1471-2458-14-713
    http://www.biomedcentral.com/1471-2458/14/713

  • Cost-effectiveness of rapid susceptibility testing against second-line drugs for tuberculosis.

  • The T2 Mycobacterium tuberculosis Genotype, Predominant in Kampala-Uganda, Shows Negative Correlation with anti-Tuberculosis Drug Resistance.

    Authored by: Lukoye Deus, Katabazi FA, Musisi K, Kateete DP, Asiimwe BB, Moses O, Joloba Moses L., Cobelens F. G.
    In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY , 2014
    http://www.ncbi.nlm.nih.gov/pubmed/24777100
    http://aac.asm.org/content/early/2014/04/22/AAC.02338-13.long

  • Operational lessons drawn from pilot implementation of Xpert MTB/Rif in Brazil

    Authored by: Betina Durovni, Valeria Saraceni, Marcelo Cordeiro-Santos, Solange Cavalcante, Elizabeth Soares, Cristina Lourenço, Alexandre Menezes , Susan van den Hof, Frank Cobelens, Anete Trajman
    In: Bulletin of the World Health Organization, 2014, ;92:613-617. doi: http://dx.doi.org/10.2471/BLT.13
    http://www.who.int/bulletin/volumes/92/8/13-131409/en/

  • Drivers and trajectories of resistance to new first-line drug regimens for tuberculosis

  • Design of pragmatic trials of tuberculosis interventions

  • Optimal triage test characteristics to improve the cost-effectiveness of the Xpert MTB/RIF assay for TB diagnosis: a decision analysis

    Authored by: van ‘t Hoog Anja, Cobelens Frank, Vassall Anna, van Kampen Sanne, Susan E Dorman, Alland David, Jerrold Ellner
    In: PLOSone, 2013, December | Volume 8 | Issue 12 | e82786
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0082786

  • Increasing Tuberculosis Notification Rates Among Young Adults are Not Associated with Migration in Da Nang, Vietnam.

    Authored by: Tiemersma Edine W., Le Van Duc, Dinh Ngoc Sy, Cobelens F. G. J.
    In: Open Infect Dis, 2013, 36-46
    http://benthamscience.com/open/toidj/articles/V007/SI0021TOIDJ/36TOIDJ.pdf

  • Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients

    Authored by: Renee Nijenbandring de Boer, João Baptista de Oliveira e Souza Filho, Cobelens F., Daniela M. De Paula Ramalho, Pryscilla Fernandes Campino Miranda, Karina de Logo, Hedi Oliveira, Eliene Mesquita, Martha Maria Oliveira, Afrânio L. Kritski
    In: Tuberculosis, 2013
    http://www.sciencedirect.com/science/article/pii/S147297921300187X

  • For Whom the Bell Tolls: Isoniazid Preventive Therapy and Tuberculosis Drug Resistance

    Authored by: Cobelens Frank G. J.
    In: SCIENCE TRANSLATIONAL MEDICINE 5(180), 2013, p.180fs12-
    http://www.ncbi.nlm.nih.gov/pubmed/23576813

  • First national tuberculin survey in Viet Nam: characteristics and association with tuberculosis prevalence

    Authored by: Hoa N. B., Cobelens F. G. J., Sy D. N., Nhung N. V., Borgdorff M. W., Tiemersma E. W.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 17(6), 2013, p.738-744
    http://www.ncbi.nlm.nih.gov/pubmed/23676155

  • Tuberculosis relapse in Vietnam is significantly associated with Mycobacterium tuberculosis Beijing genotype infections

    Authored by: Huyen Mai N. T., Buu Tran N., Tiemersma Edine, Lan Nguyen T. N., Dung Nguyen H., Kremer Kristin, Soolingen Dick V., Cobelens Frank G. J.
    In: JOURNAL OF INFECTIOUS DISEASES 207(10), 2013, p.1516-1524
    http://www.ncbi.nlm.nih.gov/pubmed/23408848

  • Epidemiology of Isoniazid Resistance Mutations and Their Effect on Tuberculosis Treatment Outcomes

    Authored by: Huyen Mai N. T., Cobelens Frank G. J., Buu Tran N., Lan Nguyen T. N., Dung Nguyen H., Kremer Kristin, Tiemersma Edine W., van Soolingen Dick
    In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 57(8), 2013, p.3620-3627
    http://www.ncbi.nlm.nih.gov/pubmed/23689727

  • Clustering of Beijing genotype Mycobacterium tuberculosis isolates from the Mekong delta in Vietnam on the basis of variable number of tandem repeat versus restriction fragment length polymorphism typing

    Authored by: Huyen Mai N. T., Kremer Kristin, Lan Nguyen T. N., Buu Tran N., Cobelens Frank G. J., Tiemersma Edine W., de Haas Petra, van Soolingen Dick
    In: BMC INFECTIOUS DISEASES 13(1), 2013, p.63-
    http://www.ncbi.nlm.nih.gov/pubmed/23375050

  • Trends in Childhood Tuberculosis in Zambia: A Situation Analysis

    Authored by: Kapata Nathan, Chanda-Kapata Pascalina, O’Grady Justin, Bates Matthew, Mwaba Peter, Janssen Saskia, Marais Ben, Cobelens Frank, Grobusch Martin, Zumla Alimuddin
    In: JOURNAL OF TROPICAL PEDIATRICS 59(2), 2013, p.134-139
    http://www.ncbi.nlm.nih.gov/pubmed/23243079

  • Alignment of new tuberculosis drug regimens and drug susceptibility testing: a framework for action

    Authored by: Wells William A., Boehme Catharina C., Cobelens Frank G. J., Daniels Colleen, Dowdy David, Gardiner Elizabeth, Gheuens Jan, Kim Peter, Kimerling Michael E., Kreiswirth Barry, Lienhardt Christian, Mdluli Khisi, Pai Madhukar, Perkins Mark D., Peter Trevor, Zignol Matteo, Zumla Alimuddin, Schito Marco
    In: LANCET INFECTIOUS DISEASES 13(5), 2013, p.449-458
    http://www.ncbi.nlm.nih.gov/pubmed/23531393

  • Combined species identification, genotyping, and drug resistance detection of Mycobacterium tuberculosis cultures by MLPA on a bead-based array

    Authored by: Bergval Indra, Sengstake Sarah, Brankova Nadia, Levterova Viktoria, Abadía Edgar, Tadumaze Nino, Bablishvili Nino, Akhalaia Maka, Tuin Kiki, Schuitema Anja, Panaiotov Stefan, Bachiyska Elizabeta, Kantardjiev Todor, de Zwaan Rina, Schürch Anita, van Soolingen Dick, van ‘t Hoog Anja, Cobelens Frank, Aspindzelashvili Rusudan, Sola Christophe, Klatser Paul, Anthony Richard
    In: PLOS ONE 7(8), 2012, p.e43240-
    http://www.ncbi.nlm.nih.gov/pubmed/22916230

  • Increased transmission of Mycobacterium tuberculosis Beijing genotype strains associated with resistance to streptomycin: a population-based study

    Authored by: Buu Tran N., van Soolingen Dick, Huyen Mai N. T., Lan Nguyen T. N., Quy Hoang T., Tiemersma Edine W., Kremer Kristin, Borgdorff Martien W., Cobelens Frank G. J.
    In: PLOS ONE 7(8), 2012, p.e42323-
    http://www.ncbi.nlm.nih.gov/pubmed/22912700

  • Relative reproductive fitness of the W-Beijing genotype

    Authored by: Cobelens Frank
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(3), 2012, p.287-

  • Which new diagnostics for tuberculosis, and when?

    Authored by: Cobelens Frank, van den Hof Susan, Pai Madhukar, Squire S. Bertel, Ramsay Andrew, Kimerling Michael E.
    In: JOURNAL OF INFECTIOUS DISEASES 205(Suppl. 2), 2012, p.S191-S198

  • Research on implementation of interventions in tuberculosis control in low- and middle-income countries: a systematic review

    Authored by: Cobelens Frank, van Kampen Sanne, Ochodo Eleanor, Atun Rifat, Lienhardt Christian
    In: PLOS MEDICINE 9(12), 2012, p.e1001358-
    http://www.ncbi.nlm.nih.gov/pubmed/23271959

  • Tuberculosis control in crisis: economic honesty and comparative effectiveness

    Authored by: Dowdy David, Vassall Anna, Cobelens Frank
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(8), 2012, p.1131-1132
    http://www.ncbi.nlm.nih.gov/pubmed/22762428

  • Multidrug Resistance Among New Tuberculosis Cases Detecting Local Variation Through Lot Quality-assurance Sampling

    Authored by: Hedt Bethany Lynn, van Leth Frank, Zignol Matteo, Cobelens Frank, van Gemert Wayne, Nhung Nguyen Viet, Lyepshina Svitlana, Egwaga Saidi, Cohen Ted
    In: EPIDEMIOLOGY 23(2), 2012, p.293-300
    http://www.ncbi.nlm.nih.gov/pubmed/22249242

  • Yield of interview screening and chest X-ray abnormalities in a tuberculosis prevalence survey

    Authored by: Hoa N. B., Cobelens F. G. J., Sy D. N., Nhung N. V., Borgdorff M. W., Tiemersma E. W.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(6), 2012, p.762-767
    http://www.ncbi.nlm.nih.gov/pubmed/22507287

  • Mixed tuberculosis infections in rural South Vietnam

    Authored by: Huyen Mai N. T., Kremer Kristin, Lan Nguyen T. N., Cobelens Frank G. J., Buu Tran N., Dung Nguyen H., Caws Maxine, Tiemersma Edine W., van Soolingen Dick
    In: JOURNAL OF CLINICAL MICROBIOLOGY 50(5), 2012, p.1586-1592
    http://www.ncbi.nlm.nih.gov/pubmed/22378903

  • Scale-up of TB and HIV programme collaborative activities in Zambia – a 10-year review

    Authored by: Kapata N., Chanda-Kapata P., Grobusch M. P., O’Grady J., Schwank S., Bates M., Jansenn S., Mwinga A., Cobelens F., Mwaba P., Zumla A.
    In: TROPICAL MEDICINE & INTERNATIONAL HEALTH 17(6), 2012, p.760-766
    http://www.ncbi.nlm.nih.gov/pubmed/22487607

  • Empirical tuberculosis treatment or improved diagnostics?

    Authored by: Manabe Yukari C., Worodria William, Cobelens Frank
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(2), 2012, p.280; author reply 280-280; author reply 281

  • Frequency and Predictors for Late Start of Antiretroviral Therapy in Primary Care Clinics, Kampala, Uganda

    Authored by: Sendagire Ibrahim, Cobelens Frank, Kambugu Andrew, Konde-Lule Joseph, Schim van der Loeff Maarten
    In: JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 61(3), 2012, p.E33-E39
    http://www.ncbi.nlm.nih.gov/pubmed/22820807

  • Urban movement and alcohol intake strongly predict defaulting from tuberculosis treatment: an operational study

    Authored by: Sendagire Ibrahim, Schim van der Loeff Maarten, Kambugu Andrew, Konde-Lule Joseph, Cobelens Frank
    In: PLOS ONE 7(5), 2012, p.e35908-
    http://www.ncbi.nlm.nih.gov/pubmed/22567119

  • Suspected tuberculosis case detection and referral in private pharmacies in Viet Nam

    Authored by: Vu D. H., van Rein N., Cobelens F. G. J., Nguyen T. T. H., Le V. H., Brouwers J. R. B. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 16(12), 2012, p.1625-1629
    http://www.ncbi.nlm.nih.gov/pubmed/23131260

  • Operational research and MDG tuberculosis control targets

    Authored by: Zumla Alimuddin, Cobelens Frank
    In: LANCET INFECTIOUS DISEASES 12(4), 2012, p.262-263
    http://www.ncbi.nlm.nih.gov/pubmed/22402009

  • Interferon-gamma release assays for tuberculosis screening of healthcare workers: a systematic review

    Authored by: Zwerling Alice, van den Hof Susan, Scholten Jerod, Cobelens Frank, Menzies Dick, Pai Madhukar
    In: THORAX 67(1), 2012, p.62-70
    http://www.ncbi.nlm.nih.gov/pubmed/21228420

  • Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study

    Authored by: Boehme Catharina C., Nicol Mark P., Nabeta Pamela, Michael Joy S., Gotuzzo Eduardo, Tahirli Rasim, Gler Ma Tarcela, Blakemore Robert, Worodria William, Gray Christen, Huang Laurence, Caceres Tatiana, Mehdiyev Rafail, Raymond Lawrence, Whitelaw Andrew, Sagadevan Kalaiselvan, Alexander Heather, Albert Heidi, Cobelens Frank, Cox Helen, Alland David, Perkins Mark D.
    In: LANCET 377(9776), 2011, p.1495-1505
    http://www.ncbi.nlm.nih.gov/pubmed/21507477

  • Household expenditure and tuberculosis prevalence in VietNam: prediction by a set of household indicators

    Authored by: Hoa N. B., Tiemersma E. W., Sy D. N., Nhung N. V., Gebhard A., Borgdorff M. W., Cobelens F. G. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 15(1), 2011, p.32-37
    http://www.ncbi.nlm.nih.gov/pubmed/21276293

  • Health-seeking behaviour among adults with prolonged cough in Vietnam

    Authored by: Hoa N. B., Tiemersma E. W., Sy D. N., Nhung N. V., Vree M., Borgdorff M. W., Cobelens F. G. J.
    In: TROPICAL MEDICINE & INTERNATIONAL HEALTH 16(10), 2011, p.1260-1267
    http://www.ncbi.nlm.nih.gov/pubmed/21692960

  • Diagnosis and Treatment of Tuberculosis in the Private Sector, Vietnam

    Authored by: Hoa Nguyen B., Cobelens Frank G. J., Sy Dinh N., Nhung Nguyen V., Borgdorff Martien W., Tiemersma Edine W.
    In: EMERGING INFECTIOUS DISEASES 17(3), 2011, p.562-564

  • Risk of travelling to the country of origin for tuberculosis among immigrants living in a low-incidence country

    Authored by: Kik S. V., Mensen M., Beltman M., Gijsberts M., van Ameijden E. J. C., Cobelens F. G. J., Erkens C., Borgdorff M. W., Verver S.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 15(1), 2011, p.38-43
    http://www.ncbi.nlm.nih.gov/pubmed/21276294

  • Effect of changing antiretroviral treatment eligibility criteria on patient load in Kampala, Uganda

    Authored by: Konde-Lule Joseph, Makumbi Fred, Pakker Nadine, Muyinda Asad, Mubiru Mesach, Cobelens Frank G. J.
    In: AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 23(1), 2011, p.35-41
    http://www.ncbi.nlm.nih.gov/pubmed/20924829

  • Operational research for improved tuberculosis control: the scope, the needs and the way forward

    Authored by: Lienhardt C., Cobelens F. G. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 15(1), 2011, p.6-13
    http://www.ncbi.nlm.nih.gov/pubmed/21276290

  • Rates of Anti-Tuberculosis Drug Resistance in Kampala-Uganda Are Low and Not Associated with HIV Infection

    Authored by: Lukoye Deus, Cobelens Frank G. J., Ezati Nicholas, Kirimunda Samuel, Adatu Francis E., Lule Joseph K., Nuwaha Fred, Joloba Moses L.
    In: PLOS ONE 6(1), 2011, p.e16130-
    http://www.ncbi.nlm.nih.gov/pubmed/21249225

  • Making innovations accessible to the poor through implementation research

    Authored by: Squire S. B., Ramsay A. R. C., van den Hof S., Millington K. A., Langley I., Bello G., Kritski A., Detjen A., Thomson R., Cobelens F., Mann G. H.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 15(7), 2011, p.862-870
    http://www.ncbi.nlm.nih.gov/pubmed/21682960

  • Measurement of exhaled nitric oxide as a potential screening tool for pulmonary tuberculosis

    Authored by: van Beek S. C., Nhung N. V., Sy D. N., Sterk P. J., Tiemersma E. W., Cobelens F. G. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 15(2), 2011, p.185-191
    http://www.ncbi.nlm.nih.gov/pubmed/21219679

  • Rapid diagnosis of tuberculosis with the Xpert MTB/RIF assay in high burden countries: a cost-effectiveness analysis

    Authored by: Vassall Anna, van Kampen Sanne, Sohn Hojoon, Michael Joy S., John K. R., den Boon Saskia, Davis J. Lucian, Whitelaw Andrew, Nicol Mark P., Gler Maria Tarcela, Khaliqov Anar, Zamudio Carlos, Perkins Mark D., Boehme Catharina C., Cobelens Frank
    In: PLOS MEDICINE 8(11), 2011, p.e1001120-
    http://www.ncbi.nlm.nih.gov/pubmed/22087078

  • Decrease in risk of tuberculosis infection despite increase in tuberculosis among young adults in urban Vietnam

    Authored by: Buu T. N., Quy H. T., Qui N. C., Lan N. T. N., Sy D. N., Cobelens F. G. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 14(3), 2010, p.289-295
    http://www.ncbi.nlm.nih.gov/pubmed/20132619

  • The Mycobacterium tuberculosis Beijing Genotype Does Not Affect Tuberculosis Treatment Failure in Vietnam

    Authored by: Buu Tran N., Huyen Mai N. T., van Soolingen Dick, Lan Nguyen T. N., Quy Hoang T., Tiemersma Edine W., Borgdorff Martien W., Cobelens Frank G. J.
    In: CLINICAL INFECTIOUS DISEASES 51(8), 2010, p.879-886
    http://www.ncbi.nlm.nih.gov/pubmed/20836697

  • Tuberculosis Acquired Outside of Households, Rural Vietnam

    Authored by: Buu Tran N., van Soolingen Dick, Huyen Mai N. T., Lan Nguyen N. T., Quy Hoang T., Tiemersma Edine W., Borgdorff Martien W., Cobelens Frank G. J.
    In: EMERGING INFECTIOUS DISEASES 16(9), 2010, p.1466-1468
    http://www.ncbi.nlm.nih.gov/pubmed/20735935

  • National anti-tuberculosis drug resistance study in Tanzania

    Authored by: Chonde T. M., Basra D., Mfinanga S. G. M., Range N., Lwilla F., Shirima R. P., van Deun A., Zignol M., Cobelens F. G., Egwaga S. M., van Leth F.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 14(8), 2010, p.967-972

  • National survey of tuberculosis prevalence in Viet Nam

    Authored by: Hoa Nguyen Binh, Sy Dinh Ngoc, Nhung Nguyen Viet, Tiemersma Edine W., Borgdorff Martien W., Cobelens Frank G. J.
    In: BULLETIN OF THE WORLD HEALTH ORGANIZATION 88(4), 2010, p.273-280

  • Validation of the GenoType(R) MTBDRplus assay for diagnosis of multidrug resistant tuberculosis in South Vietnam

    Authored by: Huyen Mai N. T., Tiemersma Edine W., Lan Nguyen T. N., Cobelens Frank G. J., Dung Nguyen H., Sy Dinh N., Buu Tran N., Kremer Kristin, Hang Pham T., Caws Maxine, O’Brien Richard, van Soolingen Dick
    In: BMC INFECTIOUS DISEASES 10(1), 2010, p.149-

  • Predictive value for progression to tuberculosis by IGRA and TST in immigrant contacts

    Authored by: Kik S. V., Franken W. P. J., Mensen M., Cobelens F. G. J., Kamphorst M., Arend S. M., Erkens C., Gebhard A., Borgdorff M. W., Verver S.
    In: EUROPEAN RESPIRATORY JOURNAL 35(6), 2010, p.1346-1353
    http://www.ncbi.nlm.nih.gov/pubmed/19840963

  • Long Delays and Missed Opportunities in Diagnosing Smear-Positive Pulmonary Tuberculosis in Kampala, Uganda: A Cross-Sectional Study

    Authored by: Sendagire Ibrahim, Schim van der Loeff Maarten, Mubiru Mesach, Konde-Lule Joseph, Cobelens Frank
    In: PLOS ONE 5(12), 2010, p.e14459-
    http://www.ncbi.nlm.nih.gov/pubmed/21206746

  • Low HIV testing rates among tuberculosis patients in Kampala, Uganda

    Authored by: Sendagire Ibrahim, Schreuder Imke, Mubiru Mesach, van der Loeff Maarten Schim, Cobelens Frank, Konde-Lule Joseph
    In: BMC PUBLIC HEALTH 10(1), 2010, p.177-

  • HIV infection among tuberculosis patients in Vietnam: prevalence and impact on tuberculosis notification rates

    Authored by: Thanh D. H., Sy D. N., Linh N. D., Hoan T. M., Dien H. T., Thuy T. B., Hoa N. P., Tung L. B., Cobelens F.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 14(8), 2010, p.986-993
    http://www.ncbi.nlm.nih.gov/pubmed/20626943

  • LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis- A TBNET consensus statement

    Authored by: Mack U., Migliori G. B., Sester M., Rieder H. L., Ehlers S., Goletti D., Bossink A., Magdorf K., Hölscher C., Kampmann B., Arend S. M., Detjen A., Bothamley G., Zellweger J. P., Milburn H., Diel R., Ravn P., Cobelens F., Cardona P. J., Kan B., Solovic I., Duarte R., Cirillo D. M.
    In: EUROPEAN RESPIRATORY JOURNAL 33(5), 2009, p.956-973
    http://www.ncbi.nlm.nih.gov/pubmed/19407047

  • Inclusion of information on risk factors, socio-economic status and health seeking in a tuberculosis prevalence survey

    Authored by: Lönnroth K., Holtz T. H., Cobelens F., Chua J., van Leth F., Tupasi T., Williams B.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 13(2), 2009, p.171-176
    http://www.ncbi.nlm.nih.gov/pubmed/19146743

  • Interferon-gamma release assays in immigrant contacts and effect of remote exposure to Mycobacterium tuberculosis

    Authored by: Kik S. V., Franken W. P. J., Arend S. M., Mensen M., Cobelens F. G. J., Kamphorst M., van Dissel J. T., Borgdorff M. W., Verver S.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 13(7), 2009, p.820-828
    http://www.ncbi.nlm.nih.gov/pubmed/19555530

  • Patient-centred tuberculosis treatment delivery under programmatic conditions in Tanzania: a cohort study

    Authored by: Egwaga Saidi, Mkopi Abdallah, Range Nyagosya, Haag-Arbenz Vera, Baraka Amuri, Grewal Penny, Cobelens Frank, Mshinda Hassan, Lwilla Fred, van Leth Frank
    In: BMC MEDICINE 7(1), 2009, p.80-
    http://www.ncbi.nlm.nih.gov/pubmed/20025724

  • Protecting patients’ rights, ensuring safety and quality assurance in tuberculosis prevalence surveys

    Authored by: Chiang C.-Y., Glaziou P., Enarson D. A., Cobelens F., Lew W.-J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 13(1), 2009, p.27-31
    http://www.ncbi.nlm.nih.gov/pubmed/19105875

  • The Beijing genotype is associated with young age and multidrug-resistant tuberculosis in rural Vietnam

    Authored by: Buu T. N., Huyen M. N., Lan N. T. N., Quy H. T., Hen N. V., Zignol M., Borgdorff M. W., Cobelens F. G. J., van Soolingen D.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 13(7), 2009, p.900-906
    http://www.ncbi.nlm.nih.gov/pubmed/19555542

  • Mycobacterium tuberculosis Genotype and Case Notification Rates, Rural Vietnam, 2003-2006

    Authored by: Buu Tran N., Huyen Mai N. T., Lan Nguyen N. T., Quy Hoang T., Hen Nguyen V., Zignol Matteo, Borgdorff Martien W., van Soolingen Dick, Cobelens Frank G. J.
    In: EMERGING INFECTIOUS DISEASES 15(10), 2009, p.1570-1577
    http://www.ncbi.nlm.nih.gov/pubmed/19861047

  • Targeted BCG Vaccination Against Severe Tuberculosis in Low-prevalence Settings Epidemiologic and Economic Assessment

    Authored by: Altes Hester Korthals, Dijkstra Frederika, Lugnèr Anna, Cobelens Frank, Wallinga Jacco
    In: EPIDEMIOLOGY 20(4), 2009, p.562-568
    http://www.ncbi.nlm.nih.gov/pubmed/19295437

  • Liquid culture for Mycobacterium tuberculosis: proceed, but with caution

    Authored by: Anthony R. M., Cobelens F. G. J., Gebhard A., Klatser P. R., Lumb R., Rüsch-Gerdes S., van Soolingen D.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 13(9), 2009, p.1051-1053
    http://www.ncbi.nlm.nih.gov/pubmed/19723391

  • Organisation of a tuberculosis prevalence survey

    Authored by: van Leth F., Cobelens F. G., Onozaki I.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 12(12), 2008, p.1365-1369

  • High tuberculosis prevalence in a psychiatric hospital in Vietnam

    Authored by: van Duc L., Vree M., Cobelens F. G., Phuc L. T., Sy D. N.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 12(6), 2008, p.686-688
    http://www.ncbi.nlm.nih.gov/pubmed/18492338

  • Tuberculosis outbreaks predicted by characteristics of first patients in a DNA fingerprint cluster

    Authored by: Kik Sandra V., Verver Suzanne, van Soolingen Dick, de Haas Petra E. W., Cobelens Frank G., Kremer Kristin, van Deutekom Henk, Borgdorff Martien W.
    In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 178(1), 2008, p.96-104
    http://www.ncbi.nlm.nih.gov/pubmed/18388352

  • Tuberculosis prevalence surveys: rationale and cost

    Authored by: Glaziou P., van der Werf M. J., Onozaki I., Dye C., Borgdorff M. W., Chiang C.-Y., Cobelens F., Enarson D. A., Gopi P. G., Holtz T. H., Kim S. J., van Leth F., Lew W.-J., Lonnroth K., van Maaren P., Narayanan P. R., Williams B.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 12(9), 2008, p.1003-1008

  • Assessment of patient preference in allocation and observation of anti-tuberculosis medication in three districts in Tanzania

    Authored by: Egwaga Saidi, Range Nyagosya, Lwilla Fred, Mkopi Abdallah, Barongo Vivien, Mtenga Sally, Mshinda Hassan, Cobelens Frank, Haag Vera, van Leth Frank, Grewal Penny
    In: PATIENT PREFERENCE AND ADHERENCE 2, 2008, p.1-6
    http://www.ncbi.nlm.nih.gov/pubmed/19920938

  • Evaluation of a large-scale tuberculosis contact investigation in the Netherlands

    Authored by: Borgen K., Koster B., Meijer H., Kuyvenhoven V., van der Sande M., Cobelens F.
    In: EUROPEAN RESPIRATORY JOURNAL 32(2), 2008, p.419-425
    http://www.ncbi.nlm.nih.gov/pubmed/18353853

  • Implementation of a national anti-tuberculosis drug resistance survey in Tanzania

    Authored by: Chonde Timothy M., Doulla Basra, van Leth Frank, Mfinanga Sayoki G. M., Range Nyagosya, Lwilla Fred, Mfaume Saidi M., van Deun Armand, Zignol Matteo, Cobelens Frank G., Egwaga Saidi M.
    In: BMC PUBLIC HEALTH 8, 2008, p.427-
    http://www.ncbi.nlm.nih.gov/pubmed/19116022

  • Scaling up programmatic management of drug-resistant tuberculosis: a prioritized research agenda

    Authored by: Cobelens Frank G. J., Heldal Einar, Kimerling Michael E., Mitnick Carole D., Podewils Laura J., Ramachandran Rajeswari, Rieder Hans L., Weyer Karin, Zignol Matteo
    In: PLOS MEDICINE 5(7), 2008, p.e150-1042
    http://www.ncbi.nlm.nih.gov/pubmed/18613746

  • Comparison of two interferon-gamma assays and tuberculin skin test for tracing tuberculosis contacts

    Authored by: Arend Sandra M., Thijsen Steven F. T., Leyten Eliane M. S., Bouwman John J. M., Franken Willeke P. J., Koster Ben F. P. J., Cobelens Frank G. J., van Houte Arend-Jan, Bossink Ailko W. J.
    In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 175(6), 2007, p.618-627
    http://www.ncbi.nlm.nih.gov/pubmed/17170386

  • Tuberculosis risks for health care workers in Africa

    Authored by: Cobelens Frank G. J.
    In: CLINICAL INFECTIOUS DISEASES 44(3), 2007, p.324-326

  • Use of Gamma-interferon assays in low- and medium-prevalence countries in Europe: a consensus statement of a Wolfheze Workshop organised by KNCV/EuroTB, Vilnius Sept 2006

    Authored by: Drobniewski F., Cobelens F., Zellweger J.-P.
    In: EURO SURVEILLANCE 12(7), 2007, p.E070726.2-
    http://www.ncbi.nlm.nih.gov/pubmed/17868554

  • Steep increases in tuberculosis notification among young men in the industrialised districts of Danang, Vietnam

    Authored by: Duc L. V., Vree M., Sy D. N., Co N. V., Borgdorff M. W., Cobelens F. G. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 11(5), 2007, p.567-570
    http://www.ncbi.nlm.nih.gov/pubmed/17439683

  • Low specificity of HIV-testing on sputum specimens kept at ambient temperatures for 4 to 7 days: a blinded comparison

    Authored by: Egwaga Saidi M., Chonde Timothy M., Matee Mecky I., Mfinanga Sayoki G., Ngowi Prosper E., Lwilla Fred, Cobelens Frank Gj
    In: BMC CLINICAL PATHOLOGY 7, 2007, p.8-
    http://www.ncbi.nlm.nih.gov/pubmed/17880720

  • Tuberculosis drug resistance and HIV infection, the Netherlands

    Authored by: Haar Catharina Hendrika, Cobelens Frank G. J., Kalisvaart Nico A., van der Have Jan J., van Gerven Paul J. H. J., van Soolingen Dick
    In: EMERGING INFECTIOUS DISEASES 13(5), 2007, p.776-778

  • Hiv-testbeleid bij tuberculosepatiënten in Nederland

    Authored by: Haar C. H., Cobelens F. G. J., Kalisvaart N. A., van der Have J. J., van Deutekom H.
    In: NEDERLANDS TIJDSCHRIFT VOOR GENEESKUNDE 151(48), 2007, p.2674-2679

  • HIV-related mortality among tuberculosis patients in The Netherlands, 1993-2001

    Authored by: Haar C. H., Cobelens F. G. J., Kalisvaart N. A., van Gerven P. J. H. J., van der Have J. J.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 11(9), 2007, p.1038-1041
    http://www.ncbi.nlm.nih.gov/pubmed/17918662

  • Fluorescence microscopy for tuberculosis diagnosis

    Authored by: Hung Nguyen Van, Sy Dinh Ngoc, Anthony Richard M., Cobelens Frank G. J., van Soolingen Dick
    In: LANCET INFECTIOUS DISEASES 7(4), 2007, p.238-9; author reply 239-40

  • Delays in the diagnosis and treatment of tuberculosis patients in Vietnam: a cross-sectional study

    Authored by: Huong Nguyen T., Vree Marleen, Duong Bui D., Khanh Vu T., Loan Vu T., Co Nguyen V., Borgdorff Martien W., Cobelens Frank G.
    In: BMC PUBLIC HEALTH 7, 2007, p.110-
    http://www.ncbi.nlm.nih.gov/pubmed/17567521

  • Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation

    Authored by: Leyten Eliane M. S., Arend Sandra M., Prins Corine, Cobelens Frank G. J., Ottenhoff Tom H. M., van Dissel Jaap T.
    In: CLINICAL AND VACCINE IMMUNOLOGY 14(7), 2007, p.880-885
    http://www.ncbi.nlm.nih.gov/pubmed/17507543

  • HIV and tuberculosis in Ho Chi Minh City, Vietnam, 1997-2002

    Authored by: Tran Ngoc Buu, Houben Rein M. G. J., Hoang Thi Quy, Nguyen Thi Ngoc Lan, Borgdorff Martien W., Cobelens Frank G. J.
    In: EMERGING INFECTIOUS DISEASES 13(10), 2007, p.1463-1469
    http://www.ncbi.nlm.nih.gov/pubmed/18257988

  • Tuberculosis trends, Vietnam

    Authored by: Vree Marleen, Bui Duc Duong, Dinh Ngoc Sy, Nguyen Viet Co, Borgdorff Martien W., Cobelens Frank G. J.
    In: EMERGING INFECTIOUS DISEASES 13(5), 2007, p.796-797

  • High mortality during tuberculosis treatment does not indicate long diagnostic delays in Vietnam: a cohort study

    Authored by: Vree Marleen, Huong Nguyen T., Duong Bui D., Co Nguyen V., Sy Dinh N., Cobelens Frank G., Borgdorff Martien W.
    In: BMC PUBLIC HEALTH 7, 2007, p.210-
    http://www.ncbi.nlm.nih.gov/pubmed/17705838

  • Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study

    Authored by: Vree Marleen, Huong Nguyen T., Duong Bui D., Sy Dinh N., van Le N., Co Nguyen V., Cobelens Frank G. J., Borgdorff Martien W.
    In: BMC PUBLIC HEALTH 7, 2007, p.134-

  • Low tuberculosis notification in mountainous Vietnam is not due to low case detection: a cross-sectional survey

    Authored by: Vree M., Hoa N. B., Sy D. N., Co N. V., Cobelens F. G. J., Borgdorff M. W.
    In: BMC INFECTIOUS DISEASES 7(1), 2007, p.109-
    http://www.ncbi.nlm.nih.gov/pubmed/17880701

  • Survival and relapse rate of tuberculosis patients who successfully completed treatment in Vietnam

    Authored by: Vree M., Huong N. T., Duong B. D., Sy D. N., van L. N., Hung N. V., Co N. V., Borgdorff M. W., Cobelens F. G.
    In: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 11(4), 2007, p.392-397
    http://www.ncbi.nlm.nih.gov/pubmed/17394684